More energy by Week 3. Sharper by Week 6. Feeling like yourself again by Week 8.
Rootwella NMN — the 10-in-1 NAD+ formula for people 40+ who are done with caffeine, B vitamins, and everything else that didn't work.
★★★★★ 4.9 · 10,258 verified reviews · 60-Day Guarantee
Every Ingredient Carefully Chosen
Every ingredient in our formula is there for a reason and backed by peer-reviewed research, not marketing fluff. We don't hide behind "proprietary blends" or vague labels. You get a clear, transparent list of clinically supported ingredients, each included at a meaningful dose.
β-NMN
NAD+ Activation — 500mg
High-purity β-NMN at 500mg, ta well-studied oral precursor to NAD+. At 500mg per serving, this matches the dose used in human clinical trials showing real improvements in energy, muscle function, and insulin sensitivity. We disclose every milligram — no hiding behind blends.
β-NMN
NAD+ Activation — 500mg
High-purity β-NMN at 500mg, ta well-studied oral precursor to NAD+. At 500mg per serving, this matches the dose used in human clinical trials showing real improvements in energy, muscle function, and insulin sensitivity. We disclose every milligram — no hiding behind blends.
Trans-Resveratrol
Sirtuin Activation — 200mg
98% pure trans-resveratrol from Japanese knotweed. Activates sirtuin longevity enzymes that work synergistically with NAD+ to enhance DNA repair and combat oxidative stress. Studies show NMN + resveratrol raises NAD+ in heart and muscle tissue significantly more than NMN alone.
Trans-Resveratrol
Sirtuin Activation — 200mg
98% pure trans-resveratrol from Japanese knotweed. Activates sirtuin longevity enzymes that work synergistically with NAD+ to enhance DNA repair and combat oxidative stress. Studies show NMN + resveratrol raises NAD+ in heart and muscle tissue significantly more than NMN alone.
TMG
Methylation Support — 500mg
Trimethylglycine replenishes the methyl groups consumed during NMN's conversion to NAD+. Without TMG, NMN can deplete your methylation pathways — affecting homocysteine levels and liver function. Most NMN brands skip this. We include it at the correct dose.
TMG
Methylation Support — 500mg
Trimethylglycine replenishes the methyl groups consumed during NMN's conversion to NAD+. Without TMG, NMN can deplete your methylation pathways — affecting homocysteine levels and liver function. Most NMN brands skip this. We include it at the correct dose.
Apigenin
NAD+ Preservation — 50mg
A natural flavonoid that inhibits CD38, the enzyme responsible for degrading NAD+ in your tissues. As you age, CD38 levels rise sharply, draining NAD+ faster than NMN can replenish it. Apigenin protects what you produce, keeping NAD+ concentrations higher for longer.
Apigenin
NAD+ Preservation — 50mg
A natural flavonoid that inhibits CD38, the enzyme responsible for degrading NAD+ in your tissues. As you age, CD38 levels rise sharply, draining NAD+ faster than NMN can replenish it. Apigenin protects what you produce, keeping NAD+ concentrations higher for longer.
CoQ10
Mitochondrial Power — 100mg
An essential electron carrier in every cell membrane. CoQ10 works in direct synergy with NAD+ inside the mitochondria to maximise cellular energy output. As NAD+ rises, CoQ10 ensures your mitochondria can fully capitalise on the increased fuel supply.
CoQ10
Mitochondrial Power — 100mg
An essential electron carrier in every cell membrane. CoQ10 works in direct synergy with NAD+ inside the mitochondria to maximise cellular energy output. As NAD+ rises, CoQ10 ensures your mitochondria can fully capitalise on the increased fuel supply.
Quercetin
Cellular Cleanup — 250mg
A plant flavonoid with senolytic properties, it clears senescent "zombie cells" that accumulate with age and accelerate biological aging. Research shows quercetin combined with NMN promotes cell protection and maximises NAD+ levels by potentiating cellular rescue effects.
Quercetin
Cellular Cleanup — 250mg
A plant flavonoid with senolytic properties, it clears senescent "zombie cells" that accumulate with age and accelerate biological aging. Research shows quercetin combined with NMN promotes cell protection and maximises NAD+ levels by potentiating cellular rescue effects.
10K+ Happy Customers
Excellent 4.9
What Real Customers Are Saying
If you've tried an NMN supplement before and felt nothing, the problem probably wasn't you — it was the product. Independent lab testing has repeatedly found NMN products that contain a fraction of their labeled dose, hidden inside "proprietary blends" you can't verify. Rootwella NMN Complex is built for the opposite kind of buyer: the one who reads the label, checks the science, and wants proof before spending a dollar.
This is a 10-in-1 NAD+ booster that pairs a clinically relevant 500mg dose of high-purity β-NMN with nine research-backed cofactors — and publishes a full Certificate of Analysis so you can confirm exactly what's in every batch.
Why NAD+ matters after 40
NAD+ is the coenzyme your cells use to turn food into usable energy. Research shows NAD+ levels decline by roughly 50% between your 20s and 50s — a drop linked in the scientific literature to lower energy, slower recovery, and reduced cellular resilience. NMN (nicotinamide mononucleotide) is one of the most direct oral precursors to NAD+, which is why it has become the most-studied molecule in longevity science.
Why NMN alone isn't enough
Raising NAD+ is only half the equation. Rootwella's formula supports the full pathway:
- β-NMN (500mg) — a well-studied NAD+ precursor, dosed to match the level used in human clinical research.
- Trans-Resveratrol (200mg) — activates sirtuin "longevity" enzymes that work alongside NAD+.
- TMG / Trimethylglycine (500mg) — replenishes methyl groups used during NMN conversion. Most brands skip this; we don't.
- Apigenin (50mg) — a flavonoid studied for inhibiting CD38, an enzyme that degrades NAD+ and rises with age.
- CoQ10 (100mg) — supports mitochondrial energy output.
- Quercetin (250mg) — a senolytic-class flavonoid researched for clearing aged "zombie" cells.
- Plus reduced glutathione, grape seed extract, astaxanthin, and fat-soluble vitamin C for antioxidant support.
Studies suggest combining NMN with resveratrol, apigenin and TMG may support greater NAD+ levels than NMN alone.
What to expect
This NAD+ supplement isn't a stimulant — it works at the cellular level, so results build gradually. Many Rootwella customers report steadier daily energy and sharper focus within the first 2–3 weeks, with physical recovery improving around weeks 4–6. Use consistently for 8–12 weeks for the full benefit.
Why choose Rootwella NMN
- Every dose disclosed — no proprietary blends; all 10 ingredients listed at full strength on the label.
- Third-party tested — independent lab verification, with the Certificate of Analysis published publicly, not "available on request."
- Clean formula — vegan, non-GMO, free from soy, gluten, dairy, and tree nuts. No fillers.
- Made in the USA in a cGMP-certified facility.
- 60-day money-back guarantee — don't feel the difference, and we'll refund you in full.
How to use: Take 2 capsules (500mg NMN) each morning, with or without food. Adults over 55 or who are highly active may take up to 4 capsules (1,000mg NMN) daily.
Have Questions?We Have Answers.
Most NMN supplements hide doses in proprietary blends — Independent lab testing has found that many NMN products on the market contain less than their labeled dose. Rootwella discloses every milligram of all 10 ingredients, names our testing lab, and publishes our Certificate of Analysis publicly so you can verify every batch before buying. Beyond transparency, our 10-in-1 formula includes synergistic cofactors (resveratrol, apigenin, TMG, CoQ10, quercetin) shown to amplify NAD+ effectiveness studies suggest combining NMN with resveratrol, apigenin and TMG may support greater NAD+ levels than NMN alone
Yes — if you're taking the right dose of a verified product. Over 30 published human clinical trials confirm NMN raises NAD+ levels in the blood and tissues. Participants report improved muscle strength, insulin sensitivity, energy, and aerobic capacity. The caveat: many cheap products don't contain the NMN they claim to. That's why the COA matters — and why we publish ours.
Most users notice increased energy and mental clarity within 2–3 weeks. Enhanced physical performance appears by week 4–6. Full anti-aging and cellular health benefits build over 8–12 weeks. NAD+ restoration works at the cellular level — it's not a stimulant effect. Don't quit at week 2: many customers who nearly stopped became the most enthusiastic users by week 6. That's why we offer 60 days to feel the difference.
Take 2 capsules (500mg NMN) every morning with or without food. For those over 55 or highly active, up to 4 capsules (1,000mg NMN) daily is well-tolerated. Morning dosing aligns with your body's natural NAD+ cycle for optimal all-day energy. Pairs well with omega-3s, vitamin D, and magnesium.
NMN is generally very well-tolerated. Clinical studies show it's safe up to 1,200mg/day with no major adverse effects. Some users experience mild digestive discomfort in the first few days — this typically resolves quickly and can be minimised by taking with food. If you're pregnant, nursing, or on prescription medication, consult your physician first.
NMN is not known to interact with common medications, but we always recommend checking with your doctor if you are on prescription drugs. However, if you're on blood thinners, diabetes medication, or treating a chronic condition, we recommend speaking with your physician before starting. We can provide a full ingredient breakdown with citations to share at your next appointment.
Each cofactor plays a distinct, peer-reviewed role. Resveratrol activates sirtuin longevity genes that work synergistically with elevated NAD+. Apigenin inhibits CD38 — an enzyme that destroys NAD+ and rises sharply with age — preserving the NAD+ you produce. TMG replenishes methyl groups consumed during NMN conversion, protecting your methylation pathways. CoQ10 amplifies mitochondrial output alongside elevated NAD+. Without these cofactors, you're raising NAD+ without protecting or leveraging it. Together, the formula supports NAD+ studies suggest combining NMN with resveratrol, apigenin and TMG may support greater NAD+ levels than NMN alone