Most NMN supplements hide doses in proprietary blends — Independent lab testing has found that many NMN products on the market contain less than their labeled dose. Rootwella discloses every milligram of all 10 ingredients. Beyond transparency, our 10-in-1 formula includes synergistic cofactors (resveratrol, apigenin, TMG, CoQ10, quercetin) shown to amplify NAD+ effectiveness studies suggest combining NMN with resveratrol, apigenin and TMG may support greater NAD+ levels than NMN alone

Yes — if you're taking the right dose of a verified product. Over 30 published human clinical trials confirm NMN raises NAD+ levels in the blood and tissues. Participants report improved muscle strength, insulin sensitivity, energy, and aerobic capacity. The caveat: many cheap products don't contain the NMN they claim to.

Most users notice increased energy and mental clarity within 2–3 weeks. Enhanced physical performance appears by week 4–6. Full anti-aging and cellular health benefits build over 8–12 weeks. NAD+ restoration works at the cellular level — it's not a stimulant effect. Don't quit at week 2: many customers who nearly stopped became the most enthusiastic users by week 6. That's why we offer 60 days to feel the difference.

Take 2 capsules (500mg NMN) every morning with or without food. For those over 55 or highly active, up to 4 capsules (1,000mg NMN) daily is well-tolerated. Morning dosing aligns with your body's natural NAD+ cycle for optimal all-day energy. Pairs well with omega-3s, vitamin D, and magnesium.

NMN is generally very well-tolerated. Clinical studies show it's safe up to 1,200mg/day with no major adverse effects. Some users experience mild digestive discomfort in the first few days — this typically resolves quickly and can be minimised by taking with food. If you're pregnant, nursing, or on prescription medication, consult your physician first.

NMN is not known to interact with common medications, but we always recommend checking with your doctor if you are on prescription drugs. However, if you're on blood thinners, diabetes medication, or treating a chronic condition, we recommend speaking with your physician before starting. We can provide a full ingredient breakdown with citations to share at your next appointment.

Each cofactor plays a distinct, peer-reviewed role. Resveratrol activates sirtuin longevity genes that work synergistically with elevated NAD+. Apigenin inhibits CD38 — an enzyme that destroys NAD+ and rises sharply with age — preserving the NAD+ you produce. TMG replenishes methyl groups consumed during NMN conversion, protecting your methylation pathways. CoQ10 amplifies mitochondrial output alongside elevated NAD+. Without these cofactors, you're raising NAD+ without protecting or leveraging it. Together, the formula supports NAD+ studies suggest combining NMN with resveratrol, apigenin and TMG may support greater NAD+ levels than NMN alone